Nicotine Sensitization in a Rodent model of Schizophrenia: A Comparison of Adolescents, Adults, and Neurotrophic factors
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Ascorbic acid inhibits nicotine-induced behavioral sensitization in male mice
Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...
متن کاملAscorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in female mice
Introduction: The influence of ascorbic acid on the nicotine-induced conditioned place preference (CPP) and behavioral sensitization was investigated in the present study. Methods: In a pilot study, place conditioning and locomotor activity were investigated after nicotine (0.25, 0.5, 0.75, 1, 1.5 and 2 mg/kg) or ascorbic acid (1, 10, 100 and 1000 mg/kg) administration. Different doses of a...
متن کاملAscorbic acid inhibits nicotine-induced behavioral sensitization in male mice
Repeated administration of nicotine causes incentive and behavioral sensitization in animals. Ascorbic acid administration inhibits some effects of nicotine. In the present study, the effect of ascorbic acid administration on nicotine-induced behavioral sensitization in Male Swiss-Webster mice (20-25 g) was investigated. Animals were injected with nicotine (0.25 mg/kg, i.p.) once daily for seve...
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The prevalence of smoking in schizophrenia patients far exceeds that in the general population. Increased vulnerability to nicotine and other drug addictions in schizophrenia may reflect the impact of developmental limbic abnormalities on cortical-striatal mediation of behavioral changes associated with drug use. Rats with neonatal ventral hippocampal lesions (NVHLs), a neurodevelopmental model...
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Objective: This project aimed to study early maladaptive schemas in adults with parents afflicted with schizophrenia. Methods: In a causal-comparative study, a sample of 39 adults with one schizophrenic parent as the experiment group and 40 students without schizophrenic parents as the control group were selected. Both groups completed early maladaptive schema questionnaire. Descriptive ...
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تاریخ انتشار 2007